2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite；

CAS: 102691-36-1；

Synonyms：

• P-REAGENT;
• 2-Cyanoethoxybis(N,N-diisopropylaMino)phosphine;
• Bis(diisopropylaMino)(2-cyano;
• N,N,N',N'-Tetrakis(1-Methylethyl)phosphorodiaMidous Acid 2-Cyanoethyl Ester;
• THERAPEUTIC GRADE PHOS REAGENT;
• 2-Cyanoethyl N,N,N',N'-tetra(prop-2-yl)phosphorodiamidoite;
• 2-Cyanoethyl N,N,N',N'-tetrakis(isopropyl)phosphorodiamidite;
• β-Cyanoethyl-N,N,N`,N`-tertraisopropylphosphorodiaMidite
• Phosphoramidites， nucleosides

Product Properties

• Boiling point: 100 °C0.5 mm Hg(lit.)
• Density: 0.949 g/mL at 25 °C(lit.)
• Refractive index: n20/D 1.470(lit.)
• Fp: 141 °F
• Storage temp: -20°C
• Pka: 6.78±0.70(Predicted)
• Form: liquid
• Sensitive: moisture sensitive, store cold
• Stability: Explodes When Heated
• modified NTPs，Protective nucleoside

Application

1.In preparation of prosphoramidite reagent, required for synthesis of 12-mer oligodeoxynucleotide.

2.As phosphorylating agent in synthesis of 1,2-diacyl-sn-glycerophosphatidylserine.

3.In situ preparation of deoxyribonucleoside phosphoramidites.

4.In preparation of 2’-deoxy-2’-fluoro-3’-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-5’ -O-(4-methoxytrityl)-4’-thio-β-D-arabinouridine and 1-(3-O-(-cyanoethyl-N,N-diisopropylphosphoramidic)-2-deoxy-2-fluoro-5-O-(4,4’-dimethoxytrityl)-4-thio-β-D-arabinofuranosyl)-thymine.

5.As reagent for synthesizing phosphitylated nucleotides.

phosphoramidite，oligonucleotide

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