Recently, the 10th China (Tianjin) Nucleic Acid Drug Conference, hosted by the China Association of Biochemical and Pharmaceutical Industries, was held with great success. At the conference, the group standard "Quality Control of Phosphoramidite Monomers" was officially released to the public, and Xinxiang Runyu Material Co., Ltd. was awarded a certificate as a participating drafting unit.
This qualification, awarded by a national-level industry association, signifies that Runyu Material has received authoritative recognition for its technological prowess, industrialization capabilities, and industry standing in the field of amidophosphoric acid monomers. The company has deeply engaged in the development of industry quality-control standards and has officially joined the ranks of China’s key enterprises supplying core upstream raw materials for nucleic acids.
The China Biochemical and Pharmaceutical Industry Association (CBPIA), which issues the certificates, was established by the former Ministry of Commerce and approved for registration by the Ministry of Civil Affairs. As the sole national-level first-tier industry association in China’s biochemical and biopharmaceutical sector, it enjoys extremely high industry authority and influence.
By participating in the drafting of group standards, the company has transformed from a mere implementer of standards into a co-builder of industry rules. This highlights Runyu Material of Xinxiang City’s profound technical expertise and practical experience in the field of quality control for amidophosphite monomers, leveraging its robust capabilities to help drive the industry toward a higher-quality development stage.
The phosphoramidite monomer is the core starting material for the chemical synthesis of oligonucleotides and small nucleic acid drugs, often referred to as the “building blocks” of nucleic acid therapeutics. The current mainstream solid-phase phosphoramidite synthesis process relies entirely on high-purity phosphoramidite monomers to achieve precise assembly of nucleic acid sequences, and is widely used in fields such as siRNA, antisense oligonucleotides, gene probes, and mRNA-related modified raw materials.
The purity of phosphoramidite monomers, impurity control, and batch-to-batch stability directly determine the coupling efficiency in downstream nucleic acid drug synthesis and the impurity levels in the final product, profoundly impacting drug development timelines and drug safety. Among the numerous raw materials used in the synthesis of phosphoramidite monomers, phosphorus reagents play a crucial role. Trivalent phosphorus impurities in phosphorus reagents can directly affect the purity of phosphoramidite monomers, their impurity control, and batch-to-batch stability. Therefore, high-quality phosphorus reagents with low impurity levels are the preferred choice for synthesizing phosphoramidite monomers.
Our invitation to participate in the drafting of the standard “Quality Control for Phosphoramidite Monomers” stems from Runyu Material’s long-term, sustained commitment to technological excellence. Xinxiang Runyu New Materials Technology Co., Ltd. specializes in the R&D and industrialization of novel organophosphorus chemicals, focusing on key upstream phosphorus reagents for the biopharmaceutical industry as well as complementary raw materials for nucleotide synthesis. The company has established a specialized R&D platform and assembled a highly skilled technical team dedicated to advancing phosphorus synthesis processes, continuously tackling challenges in the synthesis, purification, and stabilization of phosphoramidite monomers.
Through long-term R&D and mass-production practices, the company has accumulated extensive process-development data and established a comprehensive quality-control system that spans the entire chain—from raw material inspection upon arrival at the factory, through real-time monitoring of the production process, to multi-dimensional characterization of finished products. This system consistently provides domestic biopharmaceutical companies with stable, high-quality phosphoramidite monomers and associated phosphine reagents. The company’s solid process expertise, well-rounded quality-control framework, and sustained achievements in industrial-scale implementation are the core strengths that enable it to participate in the development of industry standards.
Runyu Material will continue to uphold innovation-driven development, constantly optimizing product processes, enhancing product quality, and expanding its portfolio of amidophosphite monomers and related phosphorus reagents. We are fully committed to strengthening our capabilities in supplying key upstream raw materials, thereby supporting the high-quality development of China’s small nucleic acid drug industry chain and contributing to the localization of biopharmaceuticals.
Phosphorus reagent
Chinese name: 双(二异丙基氨基)(2-氰基乙氧基)膦
English name: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamide
CAS： 102691-36-1
Molecular formula: C₁₅H₃₂N₃OP
Molecular weight: 301.41
Runyu Material now offers in-stock supplies of CAS No. 102691-36-1 phosphorus reagent—Bis(diisopropylamino)(2-cyanoethoxy)phosphine—with a current production capacity ranging from 500 kg to 800 kg per month. We ensure stable supply of this product, consistently maintaining a high-purity specification of 99.9%. The finished product is a clear, colorless liquid with no trace of trivalent phosphorus impurities and extremely low levels of pentavalent phosphorus impurities; moisture content is exceptionally well controlled. This reagent is ideally suited for advanced R&D applications such as DNA/RNA solid-phase synthesis, pharmaceutical intermediates, and organic phosphonate reactions. We provide stable quality and can supply certified inspection reports. Customized packaging options are also available upon request.
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The following is the COA for Runyu Phosphorus Reagent:
We sincerely invite colleagues from the industry to consult and discuss.
